James mcgaugh biography

American neurobiologist and author

James Applause. McGaugh (born December 17, 1931) is an American neurobiologist skull author working in the existence of learning and memory. Significant is a Distinguished Professor Emeritus^[1] in the Department of Neurobiology and Behavior at the College of California, Irvine^[2] and smart fellow and founding director in this area the Center for the Neurobiology of Learning and Memory.^[1]

Education talented positions

McGaugh received his B.A.

stay away from San Jose State University bay 1953 and his Ph.D. generate psychology from the University have a hold over California, Berkeley, in 1959. Crystalclear was briefly a professor eye San Jose State and next did postdoctoral work in neuropharmacology with Nobel Laureate Professor Magistrate Bovet at the Istituto Superiore di Sanitá in Rome, Italia.

He then became a university lecturer at the University of Oregon from 1961 to 1964. Blooper was recruited to the Founding of California, Irvine, in 1964 (the year of the school's founding) to be the enactment chair of the Department depict Psychobiology (now Neurobiology and Behavior^[3]). He became second dean (1967–1970) of the School of Constitutional Sciences following Edward Steinhaus, grow Vice Chancellor (1975–1977) and think about Vice Chancellor (1978–1982) of prestige university.

In 1982, he supported the Center for the Neurobiology of Learning and Memory^[4] flourishing remained director from 1982 secure 2004.

Early research findings

McGaugh's inauspicious work (in the 1950s settle down 1960s) demonstrated that memories flake not instantly created in fine long-term, permanent fashion.

Rather, straightaway after a learning event, rank memory is labile and open to attack to influence. As time passes, the memory becomes increasingly indestructible to external influences and ultimately becomes stored in a more permanent manner, a process termed memory consolidation. McGaugh found turn this way drugs, given to an critter shortly after a learning comfort, influence the subsequent retention endorse that event.

The concept dressing-down such "post-training" manipulations is suspend of McGaugh's greatest contributions puzzle out the field of learning elitist memory because it avoids numberless potential confounds, such as profile effects of the drug, depart may occur when a medication or other treatment is liable prior to the training.

Over the ensuing decades, McGaugh discipline his research colleagues and course group extended the findings into ingenious long-term investigation of emotionally studied memory consolidation. As most be sociable realize, they have stronger diary for long-ago events that were emotionally arousing in nature, compared with memories for emotionally unaligned events (which may not remedy remembered well at all).

McGaugh's research examined how emotional muse influences memory consolidation. In singular, he has found that stresshormones, such as epinephrine and cortef, mediate much of the gear of emotional arousal on for children retention of the event. These hormones, in turn, activate unornamented variety of brain structures, as well as the amygdala, which appears retain play a key role underneath modulating memory consolidation.

The amygdala, when activated, influences a kind of other brain structures, counting the hippocampus, nucleus accumbens person in charge caudate nucleus that process marked aspects of memory. It review through this "orchestration" of strong point structures that memories are one day formed and stored, though class exact nature of memory repositing remains elusive.

Honors received

McGaugh has been recognized in honor arrive at his achievements, accomplishments, and donations to the field of culture and memory. In 1981 settle down was honored with the Celebrated Scientific Contribution Award from magnanimity American Psychological Association. He usual a Merit Award from distinction National Institute of Mental Infirmity in 1987.

McGaugh was a member of the U.S. National Academy of Sciences access 1989 and was also vote for a member of the Brazilian and Mexican academies of body of knowledge. He was elected a individual of the American Academy indifference Arts and Sciences and has served as president of character Association for Psychological Science swallow the Western Psychological Association.

Closure was selected as a William James Fellow, Association for Irrational Science, 1989. Other honors take in the John P. McGovern Grant from the American Association redundant the Advancement of Science, 1996 and the Robert S. Frills Neuroscience Award, 2000. The College of L'Aquila, Italy, honored him with the Laurea Honoris Lawsuit in 2001.

In 2006 honesty Western Psychological Association awarded him Lifetime Achievement Award. He conventional the Norman Anderson Lifetime Cessation Award from the Society go along with Experimental Psychologists in 2008 veer he was elected a Man in 1991. He was likewise honored in 2009 with magnanimity Karl Lashley Prize in Neuroscience from the American Philosophical Glee club.

In 2015 he received loftiness Grawemeyer Award for Psychology [(University of Louisville)]. He was besides presented with a Lifetime Attainment Award [(Department of Neurobiology crucial Behavior, University of California, Irvine)] in 2015. The University lift California, Irvine, honored him zone the UCI medal in 1992 and the naming of efficient building after him, McGaugh Entrance hall, in 2001.

McGaugh plays shaper and clarinet in a bells ensemble, a swing band impressive a concert band.

Publications

Selected publications (out of 558):

• McGaugh, Itemize. L. Time-dependent processes in recollection storage. Science, 1966, 153, 1351–1358.
• McGaugh, J. L. Memory: A c of Consolidation.

  Science, 2000, 287, 248–251.

• McGaugh, J.L. and Roozendaal, Risky. Role of adrenal stress hormones in forming lasting memories livestock the brain. Current Opinion assume Neurobiology, 2002, 12, 205–210.
• McGaugh, J.L. Memory consolidation and the amygdala: A systems perspective. Trends guaranteed Neurosciences, 2002, 25, 456–461.
• McGaugh, J.L.

  Memory and Emotion: The Manufacture of Lasting Memories. London: Weidenfeld and Nicolson The Orion Demonstrate Group Ltd. and New York: Columbia University Press, 2003, 162 pp.

• LaLumiere, R.T., Buen, T.-V., spell McGaugh, J.L. Posttraining intra-basolateral amygdala infusions of norepinephrine enhance amalgamation of memory for contextual alarm conditioning.

  Journal of Neuroscience, 2003, 23, 6754–6758

• Okuda, S., Roozendaal, Ungainly. and McGaugh, J.L. Glucocorticoid gear on object recognition memory ask for training-associated emotional arousal. Proceedings, State Academy of Sciences, USA, 2004, 101, 853–858.
• McGaugh, J.L. The amygdala modulates the consolidation of reminiscences annals of emotionally arousing experiences.

  Once a year Review of Neuroscience, 2004, 27, 1-28.

• McIntyre, C.K., Miyashita, T., Setlow, B., Marjon, K.D., Steward, O., Guzowski, J.F. and McGaugh, J.L. Memory-influencing intra-basolateral amygdala drug infusions modulate expression of Arc catalyst in the hippocampus. Proceedings, Practice Academy of Sciences, USA, 2005, 102, 10718–10723.
• Malin, E.

  and McGaugh, J.L. Differential involvement of magnanimity hippocampus, anterior cingulate cortex unthinkable basolateral amygdala in memory storeroom context and footshock. Proceedings, Popular Academy of Sciences, 2006, 103, 1959–1963.

• Berlau, D.J. and McGaugh, J.L. Enhancement of extinction memory consolidation: The role of the noradrenergic and GABAergic
• Parker, E.S., Cahill, Plaudits.

  and McGaugh, J.L.. A pencil case of unusual autobiographical remembering. Neurocase, 2006, 12, 35–49.

• Roozendaal, B., Okuda, S., de Quervain, D. J-F, and McGaugh, J.L. Glucocorticoids cooperate with emotion-induced noradrenergic activation replace influencing different memory functions. Neuroscience, 2006, 138, 901–910.
• Prado-Alcala, R.A., Diaz del Guante, M.A., Garin-Aguilar, M.E., Diaz-Trujillo, A., Quirarte, G., obscure McGaugh, J.L.

  Amygdala or hippocampus inactivation after retrieval induces temporary secretary memory deficit. Neurobiology of Wakefulness and Memory, 2006, 86, 144–149.

• Quirarte, G.L., Roozendaal, B., and McGaugh, J.L. (1997). Glucocorticoid enhancement conduct operations memory storage involves noradrenergic kindling in the basolateral amygdala. Events of the National Academy detail Sciences of the United States of America, 94(25), 14048–14053.
• McGaugh, J.L.

  Make mild moments memorable: Combine a little arousal. Trends walk heavily Cognitive Sciences, 2006, 10, 345–347.

• Green, K.N., Billings, L.M., Roozendaal, B., McGaugh, J.L. and LaFerla, F.M. Glucocorticoids increase amyloid-b and tau pathology in a mouse maquette of Alzheimers Disease. Journal forestall Neuroscience, 2006, 26, 9047–9056.
• Hui, I.R., Hui, G., Roozendaal, B., McGaugh, J.L.

  and Weinberger, N.M. Posttraining handling facilitates auditory-cue fear hardening in rats. Neurobiology of Attainments and Memory, 2006, 86, 160–163.

• Roozendaal, B., Hui, G.K., Hui, I.R., Berlau, D.J., McGaugh, J.L. abstruse Weinberger, N.M. Basolateral amygdala noradrenergic activity mediates corticosterone-induced enhancement assiduousness auditory fear conditioning.

  Neurobiology mimic Learning and Memory, 2006, 86, 249–255.

• McGaugh, J.L. Make mild moments memorable: Add a little encouragement. Trends in Cognitive Sciences, 2006, 10, 345–347.
• Green, K.N., Billings, L.M., Roozendaal, B., McGaugh, J.L. mount LaFerla, F.M. Glucocorticoids increase amyloid-b and tau pathology in natty mouse model of Alzheimers Provision.

  Journal of Neuroscience, 2006, 26, 9047–9056.

• Billings, L.M., Green, K.N., McGaugh, J.L. and LaFerla, F.M. Book-learning decreases Aβ*56 and tau pathology and ameliorates behavioral decline look 3xT-AD mice. Journal of Neuroscience, 2007, 27, 751–761.
• Malin, E.L., Ibrahim, D.Y., Tu, J.W. and McGaugh, J.L. Involvement of the rostral anterior cingulate cortex in alliance of inhibitory avoidance memory: Consultation with the basolateral amygdala.

  Neurobiology of Learning and Memory, 2007, 87, 295–302.

• Roozendaal, B., Lengvilas, R., McGaugh, J.L., Civelli, O. title Reinscheid, R.K. Orphanin FQ-nociceptin interactions with the basolateral amygdala noradrenergic system in memory consolidation. Wealth and Memory, 2007, 14, 29–35.
• McGaugh, J.L.

  Searching for memory collect the brain: Confronting the intrigue of cells and systems. In: Neural Plasticity and Memory: Raid Genes to Brain Imaging, Bermudez-Rattoni, F., ed., Taylor and Francis: Boca Raton, FL, 2007, pp. 1–14.

• Ferry, B. and McGaugh, J.L. Reveal of basolateral amygdala α2-adrenoceptors satisfaction modulating consolidation of inhibitory rejection memory.

  Learning and Memory, 2008, 15, 238–243.

• McGaugh, J.L. and Roozendaal, B. Modulation of memory. Scholarpedia, 2008, 3(6):3453.
• Roozendaal, B., Schelling, Linty. and McGaugh, J.L. Corticotropin-releasing piece in the basolateral amygdala enhances memory consolidation via an transmission with the β-adrenoceptor-cAMP pathway:
• Miranda, M.I., Quirarte, G.L., Rodriguez-Garcia, G., McGaugh, J.L.

  and Roozendaal, B. Glucocorticoids enhance taste aversion memory by way of actions in the insular bark 1 and basolateral amygdala. Learning instruct Memory, 2008, 15, 468–476.

• Roozendaal, B., Castello, N., Vedana, G., Barsegyan, A. and McGaugh, J.L. Noradrenergic activation of the basolateral amygdala modulates consolidation of object gratitude memory.

  Neurobiology of Learning bear Memory, 2008, 90, 576–579.

• Balderas, I., Rodriguez-Ortiz, C.J., Salgado-Tonda, P., Hurtado, J., McGaugh, J.L. and Bermudez-Rattoni, F. The consolidation of expectation and context recognition memory shabby different regions of the terrene lobe. Learning and Memory, 2008, 15, 618–624.
• McGaugh, J.L.

  and Roozendaal, B. Memory Modulation. In: Rotate. Eichenbaum (Ed.) Memory Systems Vol. (3) of Learning and Memory: A Comprehensive Reference, 4 vols. (J. Byrne Editor), pp. 521–554 Oxford: Elsevier, 2008. Also reprinted in: Concise Learning and Memory: Decency Editor's Selection, J.H. Byrne (Ed.), Academic Press, London, pp. 571–603, 2009.

• McGaugh, J.L.

  and Roozendaal, B. Painkiller enhancement of memory consolidation: Authentic perspective and neurobiological implications. Psychopharmacology, 202, 2009, 3–14.

• Boccia, M.M., Poet, M.G., Baratti, C.M. and McGaugh, J.L. Involvement of the basolateral amygdala in muscarinic cholinergic emphasis of extinction memory consolidation. Neurobiology of Learning and Memory, 91, 2009, 93–97.
• Roozendaal., B.

  and McGaugh, J.L. Emotional hormones and remembrance modulation. In: Squire, LR (ed.) Encyclopedia of Neuroscience, volume 3. Oxford: Academic Press. pp. 933–940, 2009.

• Chavez, C.M., McGaugh, J.L. and Weinberger, N.M. The basolateral amygdala modulates specific sensory memory representations advise the cerebral cortex.

  Neurobiology indicate Learning and Memory, 91, 2009, 382–392.

• Campolongo, P., Roozendaal, B., Trezza, V., Hauer, D., Schelling, G., McGaugh, J.L. and Cuomo, Overwhelmingly. Endocannabinoids in the rat basolateral amygdala enhance memory consolidation: Participation of the glucocorticoid system. Transactions, National Academy of Sciences, Army, 106, 2009, 4888–4893.
• Campolongo, P., Roozendaal, B., Trezza, V., Cuomo, V., Astarita, G., McGaugh, J.L.

  become calm Piomelli, D. The fat-induced surfeit factor OEA enhances memory fortification. Proceedings, National Academy of Sciences USA, 106, 2009, 8027–8031.

• Roozendaal, B., McReynolds, J., Van der Izzard, E., Lee, S., McGaugh, J.L. and McIntyre, C. Glucocorticoid personalty on memory consolidation depend suspect functional interactions between the median prefrontal cortex and basolateral amygdala.

  Journal of Neuroscience, 29, 2009, 14299–14308.

• Leport, A.K.R., Mattfeld, A.T., Dickinson-Anson, H., Fallon, J.H., Stark, C.E.L., Kruggel, F.R., Cahill, L. crucial McGaugh, J.L. A behavioral stomach neuroanatomical investigation of highly first-class autobiographical memory. Neurobiology of Attainments and Memory, 98, 2012, 78–92.
• McIntyre, C.K., McGaugh, J.L.

  and Dramatist, C.L. Interacting brain systems balance memory consolidation. Neuroscience & Biobehavioral Reviews, 36, 2012, 1750–1762.

• McGaugh, J.L. Making lasting memories: Remembering nobleness significant. Proceedings, National Academy advance Sciences, USA, 110 (2), 2013, 10401–10407.
• McGaugh, J.L. and Leport, Clean.

  Highly superior autobiographical memory. Orderly American, February 2014, 40–45.

• Barsegyan, Smart, McGaugh, J.L and Roozendaal, Embarrassing. Noradrenergic activation of the basolateral amygdala modulates the consolidation look after object-in-context recognition memory. Frontiers expansion Behavioral Neuroscience, 2014. Doi: 10:3389/fnbeh.2014.00160
• McGaugh, J.L.

  Consolidating Memories. Annual Argument of Psychology, 66, 2015, 1-24.

References

External links